Gene information
Official symbol SCN10A
Official full name sodium voltage-gated channel alpha subunit 10
Gene type protein-coding gene
Chromosome3p22.2
Alias symbolNav1.8; hPN3; SNS; PN3
Gene familySodium voltage-gated channel alpha subunits
Resources
Entrez Gene 6336
HGNC HGNC:10582
Ensembl ENSG00000185313
Vega OTTHUMG00000048245
UCSC uc003ciq.4
GO terms: 41 records
GO Description Category LogP Number of genes Detail
GO:0002027 regulation of heart rate GO Biological Processes -9.97103962 23 More
GO:0003254 regulation of membrane depolarization GO Biological Processes -7.35217119 13 More
GO:0005261 cation channel activity GO Molecular Functions -1.68739377 23 More
GO:0006814 sodium ion transport GO Biological Processes -1.68216350 6 More
GO:0006937 regulation of muscle contraction GO Biological Processes -20.8046481 43 More
GO:0006942 regulation of striated muscle contraction GO Biological Processes -11.0877013 23 More
GO:0008016 regulation of heart contraction GO Biological Processes -27.6827716 55 More
GO:0019233 sensory perception of pain GO Biological Processes -10.7642352 20 More
GO:0030001 metal ion transport GO Biological Processes -7.54203733 26 More
GO:0030424 axon GO Cellular Components -6.14132550 54 More
GO:0034702 ion channel complex GO Cellular Components -2.54472403 10 More
GO:0034703 cation channel complex GO Cellular Components -2.87762227 9 More
GO:0034762 regulation of transmembrane transport GO Biological Processes -31.7284805 100 More
GO:0034765 regulation of ion transmembrane transport GO Biological Processes -18.4305966 71 More
GO:0035637 multicellular organismal signaling GO Biological Processes -4.89020616 9 More
GO:0035725 sodium ion transmembrane transport GO Biological Processes -1.81540720 5 More
GO:0042391 regulation of membrane potential GO Biological Processes -15.0641346 59 More
GO:0042475 odontogenesis of dentin-containing tooth GO Biological Processes -4.56077482 13 More
GO:0042476 odontogenesis GO Biological Processes -9.69427751 24 More
GO:0043269 regulation of ion transport GO Biological Processes -36.9814668 116 More
GO:0044057 regulation of system process GO Biological Processes -61.6610386 136 More
GO:0044325 transmembrane transporter binding GO Molecular Functions -3.08506458 7 More
GO:0046873 metal ion transmembrane transporter activity GO Molecular Functions -1.47457965 10 More
GO:0051899 membrane depolarization GO Biological Processes -3.15848951 8 More
GO:0055117 regulation of cardiac muscle contraction GO Biological Processes -9.51337974 19 More
GO:0060371 regulation of atrial cardiac muscle cell membrane depolarization GO Biological Processes -5.41391056 4 More
GO:0061337 cardiac conduction GO Biological Processes -5.79383245 8 More
GO:0086019 cell-cell signaling involved in cardiac conduction GO Biological Processes -3.56106200 4 More
GO:0086065 cell communication involved in cardiac conduction GO Biological Processes -3.81986526 5 More
GO:0086069 bundle of His cell to Purkinje myocyte communication GO Biological Processes -4.75202065 4 More
GO:0090257 regulation of muscle system process GO Biological Processes -33.9441291 67 More
GO:0098655 cation transmembrane transport GO Biological Processes -3.98966777 20 More
GO:0098660 inorganic ion transmembrane transport GO Biological Processes -4.47276690 21 More
GO:0098662 inorganic cation transmembrane transport GO Biological Processes -4.65654157 20 More
GO:0098793 presynapse GO Cellular Components -4.56552653 42 More
GO:0098797 plasma membrane protein complex GO Cellular Components -14.6387951 39 More
GO:0098889 intrinsic component of presynaptic membrane GO Cellular Components -4.93822812 13 More
GO:0098978 glutamatergic synapse GO Cellular Components -4.83590061 31 More
GO:0099056 integral component of presynaptic membrane GO Cellular Components -4.69230219 12 More
GO:1902495 transmembrane transporter complex GO Cellular Components -2.24412383 11 More
GO:1903522 regulation of blood circulation GO Biological Processes -44.9821911 79 More
Drug-Gene interaction
view
Related drugs: 76 records
Drug name Interaction type Source PMID View
afacifenacin blocker ChemblInteractions view
articaine hydrochloride blocker ChemblInteractions view
benoxinate inhibitor TdgClinicalTrialTEND 194290931713928417016423 view
benoxinate hydrochloride blocker ChemblInteractions view
benzocaine inhibitor TdgClinicalTrialTEND 1966146217967784171392841617478817016423 view
bupivacaine inhibitor TdgClinicalTrialTENDTTD 206855731713928417016423 view
carbamazepine blocker ChemblInteractions view
carboplatin PharmGKB 26194361 view
chloroprocaine inhibitor TdgClinicalTrialTEND 84187141713928417016423 view
chloroprocaine hydrochloride blocker ChemblInteractions view
cocaine inhibitor TdgClinicalTrialTEND 1713928417016423 view
conatumumab TTD view
dibucaine inhibitor TdgClinicalTrialTEND 974268487987231713928417016423 view
dibucaine hydrochloride blocker ChemblInteractions view
disopyramide phosphate blocker ChemblInteractions view
dronedarone hydrochloride blocker ChemblInteractions view
dsp-2230 blocker ChemblInteractionsTTD view
dyclonine inhibitor TdgClinicalTrialTEND 1035501217139284947697417016423 view
dyclonine hydrochloride blocker ChemblInteractions view
erlosamide blocker ChemblInteractions 10592235 view
eslicarbazepine blocker ChemblInteractions view
eslicarbazepine acetate blocker ChemblInteractions view
ethotoin blocker ChemblInteractions view
etidocaine hydrochloride blocker ChemblInteractions view
evenamide blocker ChemblInteractions view
fosphenytoin sodium blocker ChemblInteractions view
hexylcaine inhibitor TdgClinicalTrialTEND 151482571713928417016423 view
hexylcaine hydrochloride blocker ChemblInteractions view
indecainide hydrochloride blocker ChemblInteractions view
irampanel blocker ChemblInteractions view
lamotrigine blocker ChemblInteractions view
levobupivacaine inhibitor TdgClinicalTrialTEND 1641802010969308171392841109400817016423 view
lidocaine blockerinhibitor TdgClinicalTrialChemblInteractionsTEND 205855441707715319088384 view
lidocaine hydrochloride blocker ChemblInteractions view
mephenytoin blocker ChemblInteractions view
mepivacaine inhibitor TdgClinicalTrialTEND 200449881713928417016423 view
mepivacaine hydrochloride blocker ChemblInteractions view
merethoxylline procaine blocker ChemblInteractions view
mexiletine hydrochloride blocker ChemblInteractions view
moricizine hydrochloride blocker ChemblInteractions view
nerispirdine blocker ChemblInteractions view
nktr-171 blocker ChemblInteractions view
orphenadrine citrate blocker ChemblInteractions view
orphenadrine hydrochloride blocker ChemblInteractions view
oxcarbazepine blocker ChemblInteractions view
pf-04531083 blocker ChemblInteractions view
phenacemide blocker ChemblInteractions view
phenazopyridine hydrochloride blocker ChemblInteractions view
phenytoin blocker ChemblInteractions view
phenytoin sodium blocker ChemblInteractions view
prilocaine blocker ChemblInteractions view
prilocaine hydrochloride blocker ChemblInteractions view
primidone blocker ChemblInteractions view
procainamide hydrochloride blocker ChemblInteractions view
procaine inhibitor TdgClinicalTrialTEND 8581044976878821674581713928417016423 view
procaine hydrochloride blocker ChemblInteractions view
propafenone hydrochloride blocker ChemblInteractions view
proparacaine inhibitor TdgClinicalTrialTENDTTD 17139284947697417016423 view
proparacaine hydrochloride blocker ChemblInteractions view
propoxycaine hydrochloride blocker ChemblInteractions view
quinidine gluconate blocker ChemblInteractions view
quinidine polygalacturonate blocker ChemblInteractions view
quinidine sulfate blocker ChemblInteractions view
ralfinamide blocker ChemblInteractions view
rilpivirine TTD view
riluzole blocker ChemblInteractions view
ropivacaine inhibitor TdgClinicalTrialTENDTTD 107814491713928417016423 view
ropivacaine hydrochloride blocker ChemblInteractions view
rufinamide blocker ChemblInteractions view
tetracaine blocker ChemblInteractionsTTD view
tetracaine hydrochloride blocker ChemblInteractions view
tetrodotoxin TdgClinicalTrial view
tiapride TTD view
tocainide hydrochloride blocker ChemblInteractions view
topiramate blocker ChemblInteractions view
zonisamide blocker ChemblInteractions view
Related study: 1 record
Molecular factor Omics type Application Objective MI type Reference
NC_000003.12:g.38736063T>G genomics ventricular arrhythmia[prognosis (bad)] myocardial infarction Foddha H et al. Adv Clin Exp Med. 2020
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